Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations
نویسندگان
چکیده
منابع مشابه
Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine.
Metabotropic glutamate receptors (mGluRs) are coupled to effector systems through GTP-binding proteins (G-proteins) and appear to mediate slow synaptic responses in the CNS. Although mGluR-mediated increases in phosphoinositide hydrolysis have been well characterized, other mechanisms for signal transduction employed by mGluRs are poorly understood. We recently reported that the selective mGluR...
متن کاملRegulation of NMDA Receptors by Metabotropic Glutamate Receptor 7
Background: The metabotropic glutamate receptors (mGluRs) are potential novel targets for mental disorders. Results: Activation of mGluR7 significantly reduced NMDAR-mediated currents and NMDAR surface expression via an actin-dependent mechanism. Conclusion: mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function. Significance: It provides a potential mechanis...
متن کاملHomer1a-Dependent Crosstalk Between NMDA and Metabotropic Glutamate Receptors in Mouse Neurons
BACKGROUND A large number of evidences suggest that group-I metabotropic glutamate receptors (mGluR1a, 1b, 1c, 5a, 5b) can modulate NMDA receptor activity. Interestingly, a physical link exists between these receptors through a Homer-Shank multi-protein scaffold that can be disrupted by the immediate early gene, Homer1a. Whether such a versatile link supports functional crosstalk between the re...
متن کامل[Pharmacological study on metabotropic glutamate receptors on trigeminal neurons].
Glutamic acid is known to be a major excitatory transmitter in the central nervous system. The nature of its receptors on the spinal motoneuron have been well investigated and elucidated to consist of ionotropic (iGluR) as well as metabotropic glutamate receptors (mGluR). However, the role of mGluR on trigeminal motoneurons (TMN) and trigeminal sensory neurons (TSN), which play important roles ...
متن کاملcould mdma promote stemness characteristics in mouse embryonic stem cells via mglu5 metabotropic glutamate receptors?
objective: ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (mdma), is a potent neurotoxic drug. one of the mechanisms for its toxicity is the secondary release of glutamate. mouse embryonic stem cells (mescs) express only one glutamate receptor, the metabotropic glutamate receptor 5 (mglu5), which is involved in the maintenance and self-renewal of mescs. this study aims to investigate whethe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1996
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1996.tb15570.x